The three major US stock indexes opened lower collectively, with the Dow Jones Industrial Average down 0.06%, the Nasdaq Composite Index down 0.32%, and the S&P 500 Index down 0.18%. Pfizer fell nearly 5% as reports suggested it is abandoning its experimental weight loss drug development. Dell Technologies dropped more than 5% as Q3 revenue declined by 10% year-on-year, falling short of expectations. Tesla fell nearly 3% as the first batch of deliveries for its all-electric pickup truck, Cybertruck, were completed.